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Steroid injections are frequently used for neck pain because they can provide fast-acting relief by reducing inflammation, but they often come with significant drawbacks, especially with repeated use

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While this might suggest a temporal association between BMAL1 driven transcription/translation of NRF2, we cannot be certain since BMAL1 and CLOCK can each separately bind to other proteins (40, 47) and NRF2 can transcribe genes involved in xenobiotic disposition, protection from electrophiles and general stress response (48, 49)